Hormone Support with DHEA, Testosterone & Estrogen: Supplements for Healthy Aging
Who this is for: adults noticing ageārelated hormone shifts, athletes optimizing performance, and anyone curious about safe, scienceāaware ways to support energy, strength, mood, and longevity.
Key Takeaways
- DHEA is a precursor that can convert into testosterone and estrogen.
- Testosterone supports strength, bone, libido, and motivation in women and men.
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Estrogen is essential for bones, brain, heart, mood, and skinābalance matters for everyone.
- Levels typically decline with age; symptoms vary and overlap with lifestyle factors.
- Start with testing + lifestyle; use supplements to support sleep, methylation, inflammation, and nutrient gaps.
- NuGeneLabs offers atāhome health tests to personalize your plan (NAD, DNA, telomeres, metals, GI, organic acids).
- Work with a clinician before starting hormone therapy; OTC DHEA isnāt riskāfree and isnāt a universal āantiāagingā fix.
Hormones 101 (Fast)
As we age, changes in DHEA, testosterone, and estrogen can affect energy, muscle, mood, sleep, and longevity. This quick guide explains what these hormones do, how they interact, and how to personalize your plan with testing, lifestyle, and smart supplementation.
Hormones in Plain English
DHEA
Made by your adrenal glands; helps your body make sex hormones. Levels peak in early adulthood and decline with age.
Testosterone
Key for muscle, bone density, drive, and mood in all adults. Low levels can feel like fatigue, less strength, lower libido, and low mood.
Estrogen
Critical for bone strength, heart health, cognition, and stable mood. Women see bigger shifts in peri/menopause; men still need steady, small amounts.
Why Balance Matters
Too little or too much of any one hormone can cause symptoms. Because DHEA can raise testosterone or estrogen, supervision and testing are important.
Good to know: DHEA supplements are sometimes marketed for āantiāaging,ā but some time side effects are possible. Talk to your provider, especially if you have hormoneāsensitive conditions. (MedlinePlus: DHEAāS info)
How to Personalize Your Hormone Support
1) Test, then target
- NAD Profile & Cellular Energy Test ā checks 9 NAD metabolites linked to energy, redox balance, and detox capacity.
- Genomic DNA Health Test ā flags SNPs influencing methylation, detox, inflammation, and hormone pathways.
- Telomere Length & Biological Age Test ā tracks cellular aging trends that interact with hormone status.
- Blood Metals Panel ā screens toxic elements and key minerals that can disrupt endocrine balance.
- Organic Acid & Metabolomics Test and GI Health Test ā investigate energy blocks, estrobolome balance, and inflammation.
- DUTCH Test Complete ā coming soon (full sex hormones, adrenal patterns, metabolites)
2) Lock down the āhormone habitsā
Sleep 7ā9 hours (melatonin rhythm shapes sexāhormone signaling). (CDC Sleep)
Train consistently (resistance + zone 2), manage stress, prioritize protein and colorful plants, and get morning light.
3) Add supportive supplements (no hormones required)
These donāt replace medical care or prescription therapy; they support foundations that influence hormones.
- Methyl B Complex ā supports methylation for steroidāhormone metabolism and detox.
- Omegaā3 High Potency ā helps temper inflammation that can blunt anabolic signaling.
- Magnesium (citrate) ā foundational for energy, sleep quality, and enzymatic steps tied to hormone balance.
- Melatonin Calm 3 mg or Nano Melatonin ā for circadian alignment and recovery (shortāterm, situational use).
- ProstaFlo ā menās prostate & urinary comfort to support qualityāofālife while addressing lifestyle foundations.
- NAD+ PlatinumĀ® ā cellular energy & repair support that often pairs well with training and sleep optimization.
- Liver Support ā healthy estrogen metabolism & clearance
- Super Green Capsules ā phytonutrients that aid detox and hormone balance
When Is Testosterone Therapy Appropriate?
Testosterone therapy is for clinically low levels with symptoms and requires medical supervision, labs, and monitoringāit's not a generic antiāaging shortcut. (Endocrine Society Guideline)
FAQs
How do I know if low T is my issue?
Classic signs include low libido, fatigue, less strength, more abdominal fat, and low mood but these overlap with sleep, stress, and diet. A clinician will order morning labs and assess context. (MedlinePlus: Low T)
Is overātheācounter DHEA safe?
It can have side effects and isnāt a proven antiāaging pill. Discuss with your provider, particularly if you have hormoneāsensitive conditions. (MedlinePlus on DHEA)
Do men need estrogen, too?
Yes. Although men produce much smaller amounts, estrogen is essential for healthy bones, brain function, cardiovascular protection, and mood stability. In men, estrogen is made primarily from the conversion of testosterone. Extremely low estrogen can increase fracture risk, affect cognitive performance, and impact libido. This is why balanced hormone levels, not just āmore testosteroneā, are important for long-term health in both men and women.
When Prescription Therapy Makes Sense
Testosterone therapy or prescription options may help when labs confirm deficiency with symptoms. These require clinical supervision and ongoing labs. DHEA OTC use should also be supervised due to mixed evidence and potential side effects.
Safety, Simplicity, Next Steps
Begin with sleep + training + wholeāfood protein + colorful plants. Layer in the tests above to see what you need, then add supportive supplements accordingly. If labs confirm low T or complex endocrine issues, work with a licensed clinician for a supervised plan. (Endocrine Society: Patient Guide)
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This content is for educational purposes only and was developed by NuGeneLabs editorial team based on published research and practitioner insights. It is not intended to replace medical advice.
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